Reallocation of time between device-measured 24-hour movement behaviours and risk of multiple sclerosis


Short Oral

Abstract Overview

Background: Multiple sclerosis (MS) is an immune-mediated neuroinflammatory disease with an early-onset. Previous studies on the relationship between physical activity (PA) and MS provided inconsistent results. However, no study used objective measures of PA, and little is known about the association with other movement behaviours such as sedentary time.
Purpose: The objective of the study was to examine the theoretical association of reallocation of time between device-measured movement behaviours with MS risk.
Methods: This study used data from the UK Biobank cohort, and included 96,253 participants followed between 2013-2022. Incident MS cases were ascertained based on self-report, primary care, hospital inpatient data and death data. Movement behaviour was measured with an Axivity AX3 wrist-worn triaxial accelerometer. Machine-learning models were used on accelerometer data to classify the movement behaviours (sleep, sedentary behaviour, light PA and moderate-to-vigorous PA [MVPA]). Cox proportional hazards models with age as the timescale and adjusted for confounders were used to investigate how reallocating time between movement behaviours composition, modelled using isometric log-ratio pivot coordinates, was associated with MS risk.
Results: Reallocating 20 minute/day to MVPA from all other behaviours proportionally was associated with a 12% lower risk of MS (HR=0.88, 95%CI=0.81-0.95). Additionally, reallocating 20 min from any behaviour to MVPA was associated with a lower MS risk. Conversely, reallocating 20 minutes from MVPA to any other behaviour, was associated with an higher MS risk.
Conclusions: Our findings showed that reallocating time to MVPA was associated with a reduced MS risk. These results are important for planning MS prevention programs and warrant further studies to understand which type and level of PA are the most beneficial.
Practical implications: Our study provide prospective evidence in favour of the health benefits of PA and suggest that increasing time spent in MVPA would be beneficial in MS prevention.
Funding: LIH funding

Additional Authors

Name: Laurent Malisoux
Affiliation: Physical Activity, Sport and Health Research Group, Department of Precision Health, Luxembourg Institute of Health
Presenting Author: no

Delegate Media Consent

ISPAH respects your privacy and is committed to using event photographs and videos responsibly. We capture media to showcase the value of our activities through various channels, such as our website, social media, and newsletters. Please review the consent details below, with the option to opt out at any time. If you would like to know more about how ISPAH responsibly manages your privacy please view our Privacy Statement.

Purpose: ISPAH would like to capture photographs and videos during the workshops for promotional and communication purposes, including sharing content on our website, social media, newsletters, and other related materials.

Usage:

  • Photographs and videos may be edited and used in ISPAH publications, promotional materials, and online.
  • Your personal details (e.g., name, affiliation) will not be shared unless explicitly consented to in a separate agreement.

Opt-Out Option: You have the right to opt out at any time. Please notify the photographer or videographer at the event, and we will ensure that no images or videos of you are used

Confirmation *